Is AUC same as bioavailability?
Relative bioavailability and bioequivalence In pharmacology, relative bioavailability measures the bioavailability (estimated as the AUC) of a formulation (A) of a certain drug when compared with another formulation (B) of the same drug, usually an established standard, or through administration via a different route.
How does bioavailability differ from bioequivalence?
Bioavailability studies focus on determining the process and time frame by which a drug substance is released from the oral dosage form and moves to the site of action. On the other hand, bioequivalence studies focus on the performance of the drug product and usually involve comparisons of two drug products: T and R.
What is AUC in bioequivalence trials?
The common measures used in a bioequivalence study are area under the curve (AUC) and the maximum plasma concentration. Estimation of AUC requires frequent blood samples. For long half-life drugs, sampling for long periods of time may become cumbersome.
What is AUC in bioavailability?
In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance rate from the body.
How is bioavailability of a drug from AUC calculated?
- Equation 1: Vd = total amount of drug in the body ÷ plasma drug concentration.
- Equation 2: F = mass of the drug delivered to the plasma ÷ total mass of the drug administered.
- Equation 3: F = AUC for X route of administration ÷ AUC for IV administration.
What is the difference between Cmax and AUC?
Abstract. In bioequivalence studies, the maximum concentration (Cmax) is shown to reflect not only the rate but also the extent of absorption. Cmax is highly correlated with the area under the curve (AUC) contrasting blood concentration with time.
What is the difference between bioavailability and absorption?
It is suggested that absorption be defined as movement of drug across the outer mucosal membranes of the GI tract, while bioavailability be defined as availability of drug to the general circulation or site of pharmacological actions.
What does AUC represent in pharmacokinetics?
Definition. A common use of the term “area under the curve” (AUC) is found in pharmacokinetic literature. It represents the area under the plasma concentration curve, also called the plasma concentration-time profile.
How do you determine the bioavailability of a drug?
Bioavailability is calculated by comparing plasma levels of a drug given via a particular route of administration (for example, orally) with plasma drug levels achieved by IV injection. This is where the AUC comes into play (the area under the curve calculated by plotting plasma concentrations of the drug versus time).
What is Cmax in bioavailability?
Cmax is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administered and before the administration of a second dose. It is a standard measurement in pharmacokinetics.
What is bioavailability study?
A comparative bioavailability study refers to the comparison of bioavailabilities of different formulations of the same drug or different drug products. As indicated in Chow and Liu (2008), the definition of bioavailability has evolved over time with different meanings by different individuals and organizations [1].
What does AUC mean in bioavailability?
area under the curve
The area under the plasma drug concentration-time curve (AUC) reflects the actual body exposure to drug after administration of a dose of the drug and is expressed in mg*h/L. This area under the curve is dependant on the rate of elimination of the drug from the body and the dose administered.
What is the significance of AUC?
The AUC (from zero to infinity) represents the total drug exposure across time. AUC is a useful metric when trying to determine whether two formulations of the same dose (for example a capsule and a tablet) result in equal amounts of tissue or plasma exposure.
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